Nature Communications (Apr 2019)
FoxK1 and FoxK2 in insulin regulation of cellular and mitochondrial metabolism
- Masaji Sakaguchi,
- Weikang Cai,
- Chih-Hao Wang,
- Carly T. Cederquist,
- Marcos Damasio,
- Erica P. Homan,
- Thiago Batista,
- Alfred K. Ramirez,
- Manoj K. Gupta,
- Martin Steger,
- Nicolai J. Wewer Albrechtsen,
- Shailendra Kumar Singh,
- Eiichi Araki,
- Matthias Mann,
- Sven Enerbäck,
- C. Ronald Kahn
Affiliations
- Masaji Sakaguchi
- Sections of Integrative Physiology and Metabolism and Islet Cell Biology and Regenerative Medicine, Joslin Diabetes Center
- Weikang Cai
- Sections of Integrative Physiology and Metabolism and Islet Cell Biology and Regenerative Medicine, Joslin Diabetes Center
- Chih-Hao Wang
- Sections of Integrative Physiology and Metabolism and Islet Cell Biology and Regenerative Medicine, Joslin Diabetes Center
- Carly T. Cederquist
- Sections of Integrative Physiology and Metabolism and Islet Cell Biology and Regenerative Medicine, Joslin Diabetes Center
- Marcos Damasio
- Sections of Integrative Physiology and Metabolism and Islet Cell Biology and Regenerative Medicine, Joslin Diabetes Center
- Erica P. Homan
- Sections of Integrative Physiology and Metabolism and Islet Cell Biology and Regenerative Medicine, Joslin Diabetes Center
- Thiago Batista
- Sections of Integrative Physiology and Metabolism and Islet Cell Biology and Regenerative Medicine, Joslin Diabetes Center
- Alfred K. Ramirez
- Sections of Integrative Physiology and Metabolism and Islet Cell Biology and Regenerative Medicine, Joslin Diabetes Center
- Manoj K. Gupta
- Sections of Integrative Physiology and Metabolism and Islet Cell Biology and Regenerative Medicine, Joslin Diabetes Center
- Martin Steger
- Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry
- Nicolai J. Wewer Albrechtsen
- Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry
- Shailendra Kumar Singh
- Department of Host Defense, The World Premier International Research Center Initiative Immunology Frontier Research Center
- Eiichi Araki
- Department of Metabolic Medicine, Kumamoto University
- Matthias Mann
- Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry
- Sven Enerbäck
- Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, University of Gothenburg
- C. Ronald Kahn
- Sections of Integrative Physiology and Metabolism and Islet Cell Biology and Regenerative Medicine, Joslin Diabetes Center
- DOI
- https://doi.org/10.1038/s41467-019-09418-0
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 17
Abstract
Insulin signaling represses Forkhead transcription factor FoxO activity, which contributes to organismal metabolism. Here, the authors use proteomics to identify positively regulated insulin signaling targets FoxK1/K2 and demonstrate their role in lipid metabolism and mitochondrial regulation.
