Cardio-centric hemodynamic management improves spinal cord oxygenation and mitigates hemorrhage in acute spinal cord injury

Alexandra M. Williams; Neda Manouchehri; Erin Erskine; Keerit Tauh; Kitty So; Katelyn Shortt; Megan Webster; Shera Fisk; Avril Billingsley; Alex Munro; Seth Tigchelaar; Femke Streijger; Kyoung-Tae Kim; Brian K. Kwon; Christopher R. West

doi:10.1038/s41467-020-18905-8

Nature Communications (Oct 2020)

Cardio-centric hemodynamic management improves spinal cord oxygenation and mitigates hemorrhage in acute spinal cord injury

Alexandra M. Williams,
Neda Manouchehri,
Erin Erskine,
Keerit Tauh,
Kitty So,
Katelyn Shortt,
Megan Webster,
Shera Fisk,
Avril Billingsley,
Alex Munro,
Seth Tigchelaar,
Femke Streijger,
Kyoung-Tae Kim,
Brian K. Kwon,
Christopher R. West

Affiliations

Alexandra M. Williams: International Collaboration On Repair Discoveries (ICORD), University of British Columbia
Neda Manouchehri: International Collaboration On Repair Discoveries (ICORD), University of British Columbia
Erin Erskine: International Collaboration On Repair Discoveries (ICORD), University of British Columbia
Keerit Tauh: International Collaboration On Repair Discoveries (ICORD), University of British Columbia
Kitty So: International Collaboration On Repair Discoveries (ICORD), University of British Columbia
Katelyn Shortt: International Collaboration On Repair Discoveries (ICORD), University of British Columbia
Megan Webster: International Collaboration On Repair Discoveries (ICORD), University of British Columbia
Shera Fisk: International Collaboration On Repair Discoveries (ICORD), University of British Columbia
Avril Billingsley: International Collaboration On Repair Discoveries (ICORD), University of British Columbia
Alex Munro: International Collaboration On Repair Discoveries (ICORD), University of British Columbia
Seth Tigchelaar: International Collaboration On Repair Discoveries (ICORD), University of British Columbia
Femke Streijger: International Collaboration On Repair Discoveries (ICORD), University of British Columbia
Kyoung-Tae Kim: International Collaboration On Repair Discoveries (ICORD), University of British Columbia
Brian K. Kwon: International Collaboration On Repair Discoveries (ICORD), University of British Columbia
Christopher R. West: International Collaboration On Repair Discoveries (ICORD), University of British Columbia

DOI: https://doi.org/10.1038/s41467-020-18905-8
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 12

Abstract

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Clinical neuroprotective strategies for acute spinal cord injury (SCI) have largely overlooked the heart. Here the authors show cardiac contractility is immediately impaired in a porcine model of T2 SCI, and cardio-centric treatment with dobutamine optimizes cord oxygenation and mitigates haemorrhage.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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