Nature Communications (Nov 2021)
Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma
- Tatenda Mahlokozera,
- Bhuvic Patel,
- Hao Chen,
- Patrick Desouza,
- Xuan Qu,
- Diane D. Mao,
- Daniel Hafez,
- Wei Yang,
- Rukayat Taiwo,
- Mounica Paturu,
- Afshin Salehi,
- Amit D. Gujar,
- Gavin P. Dunn,
- Nima Mosammaparast,
- Allegra A. Petti,
- Hiroko Yano,
- Albert H. Kim
Affiliations
- Tatenda Mahlokozera
- Department of Neurological Surgery, Washington University School of Medicine
- Bhuvic Patel
- Department of Neurological Surgery, Washington University School of Medicine
- Hao Chen
- Department of Neurological Surgery, Washington University School of Medicine
- Patrick Desouza
- Department of Neurological Surgery, Washington University School of Medicine
- Xuan Qu
- Department of Neurological Surgery, Washington University School of Medicine
- Diane D. Mao
- Department of Neurological Surgery, Washington University School of Medicine
- Daniel Hafez
- Department of Neurological Surgery, Washington University School of Medicine
- Wei Yang
- Department of Neurology, Washington University School of Medicine
- Rukayat Taiwo
- Department of Neurological Surgery, Washington University School of Medicine
- Mounica Paturu
- Department of Neurological Surgery, Washington University School of Medicine
- Afshin Salehi
- Department of Neurological Surgery, Washington University School of Medicine
- Amit D. Gujar
- Department of Neurological Surgery, Washington University School of Medicine
- Gavin P. Dunn
- Department of Neurological Surgery, Washington University School of Medicine
- Nima Mosammaparast
- Department of Pathology and Immunology, Washington University School of Medicine
- Allegra A. Petti
- Department of Neurological Surgery, Washington University School of Medicine
- Hiroko Yano
- Department of Neurological Surgery, Washington University School of Medicine
- Albert H. Kim
- Department of Neurological Surgery, Washington University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-021-26653-6
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 16
Abstract
SOX2 is required for the maintenance of glioblastoma stem cells (GSCs). Here the authors identify that the RING family E3 ubiquitin ligase TRIM26 promotes SOX2 stability in a non-canonical ligase-independent manner and thus, increases the tumorigenicity of GSCs.
