Arabian Journal of Chemistry (Mar 2021)
Two Zn(II) coordination polymers: Selective detection Fe3+ ion and inhibitory activity on the liver cancer viability by regulating the prolyl hydroxylase-3
Abstract
In the current study, via utilizing a mixed-ligand method, two new coordination polymers (CPs) of {[Zn5(pmbcd)2(μ3-OH)2(H2O)4(DMF)2]·4DMF}n (1) and {[Zn2(pmbcd)(bpea)2]·2H2O·2DMF}n (2) (in which bpea = 1,2-bis(4-pyridyl)ethane and H4pmbcd = 9,9′-(1,4-phenylenebis(methylene))bis(9H-carbazole-3,6-dicarboxylic acid)) have been successfully prepared using a tetracarboxylate ligand H4pmbcd without or with the present of the second co-ligand bpea. Furthermore, in the water, the complex 1 containing Zn5 clusters exhibits the strong blue luminescence, which can only be selectively quenched via the contaminant Fe3+ ion. For the treatment of liver cancer, the Cell Counting Kit-8 assay was implemented for the assessment of the compounds’ inhibition on the HepG2 liver cancer cells viability. Moreover, the prolyl hydroxylase-3 relative expression in HepG2 liver cancer cells was also detected by the real time reverse transcription polymerase chain reaction.