GABAergic inhibition in dual-transmission cholinergic and GABAergic striatal interneurons is abolished in Parkinson disease

N. Lozovaya; S. Eftekhari; R. Cloarec; L. A. Gouty-Colomer; A. Dufour; B. Riffault; M. Billon-Grand; A. Pons-Bennaceur; N. Oumar; N. Burnashev; Y. Ben-Ari; C. Hammond

doi:10.1038/s41467-018-03802-y

Nature Communications (Apr 2018)

GABAergic inhibition in dual-transmission cholinergic and GABAergic striatal interneurons is abolished in Parkinson disease

N. Lozovaya,
S. Eftekhari,
R. Cloarec,
L. A. Gouty-Colomer,
A. Dufour,
B. Riffault,
M. Billon-Grand,
A. Pons-Bennaceur,
N. Oumar,
N. Burnashev,
Y. Ben-Ari,
C. Hammond

Affiliations

N. Lozovaya: B&A Therapeutics, Ben-Ari Institute of Neuroarcheology, Batiment Beret-Delaage, zone Luminy entreprises
S. Eftekhari: Neurochlore, Ben-Ari Institute of Neuroarcheology, Batiment Beret-Delaage, Zone Luminy Biotech Entreprises
R. Cloarec: Neurochlore, Ben-Ari Institute of Neuroarcheology, Batiment Beret-Delaage, Zone Luminy Biotech Entreprises
L. A. Gouty-Colomer: Neurochlore, Ben-Ari Institute of Neuroarcheology, Batiment Beret-Delaage, Zone Luminy Biotech Entreprises
A. Dufour: Neurochlore, Ben-Ari Institute of Neuroarcheology, Batiment Beret-Delaage, Zone Luminy Biotech Entreprises
B. Riffault: Neurochlore, Ben-Ari Institute of Neuroarcheology, Batiment Beret-Delaage, Zone Luminy Biotech Entreprises
M. Billon-Grand: Neurochlore, Ben-Ari Institute of Neuroarcheology, Batiment Beret-Delaage, Zone Luminy Biotech Entreprises
A. Pons-Bennaceur: INMED, INSERM U901 and Aix-Marseille University
N. Oumar: B&A Therapeutics, Ben-Ari Institute of Neuroarcheology, Batiment Beret-Delaage, zone Luminy entreprises
N. Burnashev: INMED, INSERM U901 and Aix-Marseille University
Y. Ben-Ari: B&A Therapeutics, Ben-Ari Institute of Neuroarcheology, Batiment Beret-Delaage, zone Luminy entreprises
C. Hammond: B&A Therapeutics, Ben-Ari Institute of Neuroarcheology, Batiment Beret-Delaage, zone Luminy entreprises

DOI: https://doi.org/10.1038/s41467-018-03802-y
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 14

Abstract

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Cholinergic interneurons of the striatum are involved reward-related behaviors and have been implicated in Parkinson’s disease. Here the authors report that half of cholinergic neurons co-release acetylcholine and GABA, and study the role of these neurons in a model of Parkinson’s Disease.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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