CORRECTION OF TINNITUS AND NEUROPSYCHOLOGICAL STATUS OF PATIENTS WITH CEREBRAL ATHEROSCLEROSIS AND ESSENTIAL HYPERTENSION USING CITICOLINE AS PART OF COMPREHENSIVE THERAPY

Abstract

Objective: to analyze the effect of neuroprotective therapy with citicoline in combination with hypotensive and hypolipidemic therapy on the correction of tinnitus and neuropsychological status in patients with atherosclerosis of the brachiocephalic and cerebral arteries and essential hypertension. Materials and methods. We examined 86 patients aged between 60 and 68 years with essential hypertension and atherosclerosis of the brachiocephalic and cerebral arteries. All patients were diagnosed with decompensated tinnitus that affected their quality of life. The Multidimensional Fatigue Inventory (MFI) was used to assess the severity of asthenic syndrome. The cognitive status was evaluated using the Schulte tables, word pair memory tests, and phrase pair memory tests. Study participants were divided into two groups. Patients in Group 1 (n = 43) received nootropic therapy with citicoline at a dose of 1000 mg/day for 3 months in addition to standard hypotensive, hypolipidemic, and antiplatelet therapies. We found that citicoline as a part of comprehensive therapy facilitated regression of actual and moderate tinnitus in patients with atherosclerosis of the brachiocephalic and cerebral arteries and essential hypertension. This optimized the neurovegetative status of patients and improved their cognitive functions.

Keywords

• tinnitus
• neuropsychological status
• asthenia
• cognitive functions
• cerebral atherosclerosis
• arterial hypertension
• citicoline