Intrinsic cardiac adrenergic cells contribute to LPS-induced myocardial dysfunction

Duomeng Yang; Xiaomeng Dai; Yun Xing; Xiangxu Tang; Guang Yang; Andrew G. Harrison; Jason Cahoon; Hongmei Li; Xiuxiu Lv; Xiaohui Yu; Penghua Wang; Huadong Wang

doi:10.1038/s42003-022-03007-6

Communications Biology (Jan 2022)

Intrinsic cardiac adrenergic cells contribute to LPS-induced myocardial dysfunction

Duomeng Yang,
Xiaomeng Dai,
Yun Xing,
Xiangxu Tang,
Guang Yang,
Andrew G. Harrison,
Jason Cahoon,
Hongmei Li,
Xiuxiu Lv,
Xiaohui Yu,
Penghua Wang,
Huadong Wang

Affiliations

Duomeng Yang: Department of Pathophysiology, Key Laboratory of State Administration of Traditional Chinese Medicine of the People’s Republic of China, School of Medicine, Jinan University
Xiaomeng Dai: Department of Pathophysiology, Key Laboratory of State Administration of Traditional Chinese Medicine of the People’s Republic of China, School of Medicine, Jinan University
Yun Xing: Department of Pathophysiology, Key Laboratory of State Administration of Traditional Chinese Medicine of the People’s Republic of China, School of Medicine, Jinan University
Xiangxu Tang: Department of Pathophysiology, Key Laboratory of State Administration of Traditional Chinese Medicine of the People’s Republic of China, School of Medicine, Jinan University
Guang Yang: Department of Pathogen biology, School of Medicine, Jinan University
Andrew G. Harrison: Department of Immunology, University of Connecticut Health Center
Jason Cahoon: Department of Immunology, University of Connecticut Health Center
Hongmei Li: Department of Pathophysiology, Key Laboratory of State Administration of Traditional Chinese Medicine of the People’s Republic of China, School of Medicine, Jinan University
Xiuxiu Lv: Department of Pathophysiology, Key Laboratory of State Administration of Traditional Chinese Medicine of the People’s Republic of China, School of Medicine, Jinan University
Xiaohui Yu: Department of Pathophysiology, Key Laboratory of State Administration of Traditional Chinese Medicine of the People’s Republic of China, School of Medicine, Jinan University
Penghua Wang: Department of Immunology, University of Connecticut Health Center
Huadong Wang: Department of Pathophysiology, Key Laboratory of State Administration of Traditional Chinese Medicine of the People’s Republic of China, School of Medicine, Jinan University

DOI: https://doi.org/10.1038/s42003-022-03007-6
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 14

Abstract

Read online

Yang et al report that intrinsic cardiac adrenergic cell-derived norepinephrine promotes myocardial dysfunction in response to LPS. They demonstrate norepinephrine produced by these cells activated β1-adrenergic receptors on cardiomyocytes increasing the expression of tumor necrosis factor-a in a Ca2+/calmodulin-dependent protein kinase II dependent manner.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal