RNA modification landscape of the human mitochondrial tRNALys regulates protein synthesis

Uwe Richter; Molly E. Evans; Wesley C. Clark; Paula Marttinen; Eric A. Shoubridge; Anu Suomalainen; Anna Wredenberg; Anna Wedell; Tao Pan; Brendan J. Battersby

doi:10.1038/s41467-018-06471-z

Nature Communications (Sep 2018)

RNA modification landscape of the human mitochondrial tRNALys regulates protein synthesis

Uwe Richter,
Molly E. Evans,
Wesley C. Clark,
Paula Marttinen,
Eric A. Shoubridge,
Anu Suomalainen,
Anna Wredenberg,
Anna Wedell,
Tao Pan,
Brendan J. Battersby

Affiliations

Uwe Richter: Institute of Biotechnology, University of Helsinki
Molly E. Evans: Department of Biochemistry and Molecular Biology, University of Chicago
Wesley C. Clark: Department of Biochemistry and Molecular Biology, University of Chicago
Paula Marttinen: Institute of Biotechnology, University of Helsinki
Eric A. Shoubridge: Department of Human Genetics, Montreal Neurological Institute, McGill University
Anu Suomalainen: Research Programs Unit - Molecular Neurology, University of Helsinki
Anna Wredenberg: Department of Medical Biochemistry and Biophysics, Karolinska Institutet
Anna Wedell: Centre for Inherited Metabolic Diseases, Karolinska University Hospital
Tao Pan: Department of Biochemistry and Molecular Biology, University of Chicago
Brendan J. Battersby: Institute of Biotechnology, University of Helsinki

DOI: https://doi.org/10.1038/s41467-018-06471-z
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 11

Abstract

Read online

Mutations in mitochondrially-encoded tRNA genes can lead to mitochondrial disorders. Here the authors use next generation RNA sequencing to reveal the role of a N1 -methyladenosine modification in tRNALys MERR patients for translation elongation and the stability of selected nascent chains.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal