Nature Communications (Sep 2018)
RNA modification landscape of the human mitochondrial tRNALys regulates protein synthesis
Abstract
Mutations in mitochondrially-encoded tRNA genes can lead to mitochondrial disorders. Here the authors use next generation RNA sequencing to reveal the role of a N1 -methyladenosine modification in tRNALys MERR patients for translation elongation and the stability of selected nascent chains.