New Metabolites from Endophytic Fungus <i>Chaetomium globosum</i> CDW7
Wei Yan,
Ling-Ling Cao,
Yang-Yang Zhang,
Ran Zhao,
Shuang-Shuang Zhao,
Babar Khan,
Yong-Hao Ye
Affiliations
Wei Yan
State & Local Joint Engineering Research Center of Green Pesticide Invention and Application, College of How Plant Protection, Nanjing Agricultural University, Nanjing 210095, China
Ling-Ling Cao
State & Local Joint Engineering Research Center of Green Pesticide Invention and Application, College of How Plant Protection, Nanjing Agricultural University, Nanjing 210095, China
Yang-Yang Zhang
State & Local Joint Engineering Research Center of Green Pesticide Invention and Application, College of How Plant Protection, Nanjing Agricultural University, Nanjing 210095, China
Ran Zhao
State & Local Joint Engineering Research Center of Green Pesticide Invention and Application, College of How Plant Protection, Nanjing Agricultural University, Nanjing 210095, China
Shuang-Shuang Zhao
State & Local Joint Engineering Research Center of Green Pesticide Invention and Application, College of How Plant Protection, Nanjing Agricultural University, Nanjing 210095, China
Babar Khan
State & Local Joint Engineering Research Center of Green Pesticide Invention and Application, College of How Plant Protection, Nanjing Agricultural University, Nanjing 210095, China
Yong-Hao Ye
State & Local Joint Engineering Research Center of Green Pesticide Invention and Application, College of How Plant Protection, Nanjing Agricultural University, Nanjing 210095, China
Five metabolites including two new ones, prochaetoviridin A (1) and chaetoindolin A (2), were isolated from the endophytic fungus Chaetomium globosum CDW7. Compounds 1 and 2 were characterized as an isocoumarin and an indole alkaloid derivative, respectively, with their structures elucidated by comprehensive spectroscopic analyses including high-resolution electrospray ionization mass spectrometry (HR-ESI-MS), NMR, and circular dichroism (CD) comparison. Compounds 3⁻5 were identified as chaetoviridin A, chaetoglobosin R, and chaetoglobosin T, respectively. Chaetoviridin A (3) exhibited antifungal activity against Sclerotinia sclerotiorum with an EC50 value of 1.97 μg/mL. In vivo test showed that 3 displayed a protective efficacy of 64.3% against rape Sclerotinia rot at the dosage of 200 μg/mL, comparable to that of carbendazim (69.2%).
