Nature Communications (Oct 2018)

Damage-induced reactive oxygen species enable zebrafish tail regeneration by repositioning of Hedgehog expressing cells

  • Maria Montserrat Garcia Romero,
  • Gareth McCathie,
  • Philip Jankun,
  • Henry Hamilton Roehl

DOI
https://doi.org/10.1038/s41467-018-06460-2
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 11

Abstract

Read online

Reactive oxygen species (ROS) are required to initiate regeneration but the mechanisms regulating its production are unclear. Here, the authors show in zebrafish larval tail regeneration that ROS is released by mobilised notochord cells enables their repositioning in the damage site, assisted by secreted Hh.