Nature Communications (Jun 2021)

Allosteric drug transport mechanism of multidrug transporter AcrB

  • Heng-Keat Tam,
  • Wuen Ee Foong,
  • Christine Oswald,
  • Andrea Herrmann,
  • Hui Zeng,
  • Klaas M. Pos

DOI
https://doi.org/10.1038/s41467-021-24151-3
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 10

Abstract

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Gram-negative bacteria can display intrinsic antibiotic resistance due to the action of tripartite efflux pumps, which include a H+/drug antiporter component. Here, the authors present a structure-function analysis of antiporter AcrB in intermediate states of the transport cycle, showing novel drug-binding sites and transport pathways.