Intragenic amplification of PAX5: a novel subgroup in B-cell precursor acute lymphoblastic leukemia?

• Claire Schwab,
• Karin Nebral,
• Lucy Chilton,
• Cristina Leschi,
• Esmé Waanders,
• Judith M. Boer,
• Markéta Žaliová,
• Rosemary Sutton,
• Ingegerd Ivanov Öfverholm,
• Kentaro Ohki,
• Yuka Yamashita,
• Stefanie Groeneveld-Krentz,
• Eva Froňková,
• Marleen Bakkus,
• Joelle Tchinda,
• Thayana da Conceição Barbosa,
• Grazia Fazio,
• Wojciech Mlynarski,
• Agata Pastorczak,
• Giovanni Cazzaniga,
• Maria S. Pombo-de-Oliveira,
• Jan Trka,
• Renate Kirschner-Schwabe,
• Toshihiko Imamura,
• Gisela Barbany,
• Martin Stanulla,
• Andishe Attarbaschi,
• Renate Panzer-Grümayer,
• Roland P. Kuiper,
• Monique L. den Boer,
• Hélène Cavé,
• Anthony V. Moorman,
• Christine J. Harrison,
• Sabine Strehl

Affiliations

Claire Schwab

Leukaemia Research Cytogenetics Group, Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom;

Karin Nebral

Children's Cancer Research Institute, St Anna Kinderkrebsforschung, Vienna, Austria;

Lucy Chilton

Leukaemia Research Cytogenetics Group, Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom;

Cristina Leschi

INSERM Unité Mixte de Recherché 1131, Institut Universitaire d'Hématologie, Université Paris Diderot, Paris Sorbonne Cité, Paris, France;; Département de Génétique, Hôpital Robert Debré, Assistance Publique–Hôpitaux de Paris, Paris, France;

Esmé Waanders

Department of Human Genetics, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands;

Judith M. Boer

Department of Pediatric Oncology, Erasmus MC–Sophia Children's Hospital, Rotterdam, The Netherlands;

Markéta Žaliová

Department of Pediatrics, University Hospital Schleswig-Holstein, Kiel, Germany;; Childhood Leukaemia Investigation Prague, Department of Pediatric Hematology/Oncology, 2nd Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic;

Rosemary Sutton

Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, Australia;

Ingegerd Ivanov Öfverholm

Clinical Genetics Section, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden;

Kentaro Ohki

Department of Pediatric Hematology and Oncology, National Center for Child Health and Development, Tokyo, Japan;

Yuka Yamashita

Clinical Research Center, Nagoya Medical Center, National Hospital Organization, Aichi, Japan;

Stefanie Groeneveld-Krentz

Division of Oncology and Hematology, Department of Pediatrics, Charité–Universitätsmedizin Berlin, Berlin, Germany;

Eva Froňková

Childhood Leukaemia Investigation Prague, Department of Pediatric Hematology/Oncology, 2nd Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic;

Marleen Bakkus

Department of Hematology, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium;

Joelle Tchinda

Pediatric Oncology, Children's Research Centre, University Children's Hospital Zürich, Zürich, Switzerland;

Thayana da Conceição Barbosa

Pediatric Hematology-Oncology Program, Research Center, Instituto Nacional de Câncer, Rio de Janeiro, Brazil;

Grazia Fazio

Centro Ricerca Tettamanti, Clinica Pediatrica, Università di Milano-Bicocca, Monza, Italy;

Wojciech Mlynarski

Department of Pediatrics, Oncology, Hematology and Diabetology, Medical University of Lodz, Lodz, Poland;

Agata Pastorczak

Department of Pediatrics, Oncology, Hematology and Diabetology, Medical University of Lodz, Lodz, Poland;

Giovanni Cazzaniga

Centro Ricerca Tettamanti, Clinica Pediatrica, Università di Milano-Bicocca, Monza, Italy;

Maria S. Pombo-de-Oliveira

Pediatric Hematology-Oncology Program, Research Center, Instituto Nacional de Câncer, Rio de Janeiro, Brazil;

Jan Trka

Childhood Leukaemia Investigation Prague, Department of Pediatric Hematology/Oncology, 2nd Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic;

Renate Kirschner-Schwabe

Division of Oncology and Hematology, Department of Pediatrics, Charité–Universitätsmedizin Berlin, Berlin, Germany;; German Cancer Consortium and German Cancer Research Center, Heidelberg, Germany;

Toshihiko Imamura

Department of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan;

Gisela Barbany

Clinical Genetics Section, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden;

Martin Stanulla

Department of Pediatric Hematology and Oncology, Medical School Hannover, Hannover, Germany;

Andishe Attarbaschi

Department of Pediatric Hematology and Oncology, St Anna Children's Hospital, Medical University of Vienna, Austria; and

Renate Panzer-Grümayer

Children's Cancer Research Institute, St Anna Kinderkrebsforschung, Vienna, Austria;

Roland P. Kuiper

Department of Human Genetics, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands;

Monique L. den Boer

Department of Pediatric Oncology, Erasmus MC–Sophia Children's Hospital, Rotterdam, The Netherlands;; Dutch Childhood Oncology Group, The Hague, The Netherlands

Hélène Cavé

INSERM Unité Mixte de Recherché 1131, Institut Universitaire d'Hématologie, Université Paris Diderot, Paris Sorbonne Cité, Paris, France;; Département de Génétique, Hôpital Robert Debré, Assistance Publique–Hôpitaux de Paris, Paris, France;

Anthony V. Moorman

Leukaemia Research Cytogenetics Group, Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom;

Christine J. Harrison

Leukaemia Research Cytogenetics Group, Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom;; Christine J. Harrison, Leukaemia Research Cytogenetics Group, Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Level 6, Herschel Building, Newcastle-upon-Tyne NE1 7RU, United Kingdom;

Sabine Strehl

Children's Cancer Research Institute, St Anna Kinderkrebsforschung, Vienna, Austria;; Sabine Strehl, Children's Cancer Research Institute, St Anna Kinderkrebsforschung, Zimmermannplatz 10, 1090 Vienna, Austria;