Liraglutide in the treatment of type 2 diabetes mellitus: clinical utility and patient perspectives

Abstract

Mahamood Edavalath1, Jeffrey W Stephens1,21Department of Diabetes and Endocrinology, Morriston Hospital, ABM University NHS Trust, Swansea, UK; 2Diabetes Research Group, Institute of Life Sciences, Swansea University, Swansea, UKAbstract: Type 2 diabetes mellitus (T2DM) is a progressive disease associated with significant morbidity and mortality. There is good evidence that intensive glycemic control reduces the development and progression of complications in patients with diabetes. In order to achieve glycemic targets, patients often require a combination of oral therapy and/or insulin in addition to lifestyle modification. Unfortunately many currently available therapies for T2DM are associated with weight gain and hypoglycemia resulting in poor compliance and  subsequent worsening glycemic control. Glucagon like peptide-1 (GLP-1) is an incretin hormone secreted from the small intestine that lowers fasting and postprandial glucose through multiple mechanisms including glucose-dependent insulin secretion, reduction of glucagon secretion, delaying gastric emptying and increased satiety. Liraglutide is a long acting GLP-1 mimetic that is administered once a day by subcutaneous injection and is now licensed for the treatment of T2DM. Phase 3 clinical trials have demonstrated beneficial effects on glycemic control and weight with liraglutide therapy. Within this article, we provide an overview of pharmacology, efficacy, safety and patient experience on liraglutide in the management of T2DM.Keywords: liraglutide, type 2 diabetes mellitus, glycemic control, GLP-1 analogue, obesity