Microglia and Astrocytes in Alzheimer’s Disease in the Context of the Aberrant Copper Homeostasis Hypothesis
Amit Pal,
Isha Rani,
Anil Pawar,
Mario Picozza,
Mauro Rongioletti,
Rosanna Squitti
Affiliations
Amit Pal
Department of Biochemistry, AIIMS, Kalyani 741245, West Bengal, India
Isha Rani
Department of Biochemistry, Maharishi Markandeshwar Institute of Medical Sciences and Research (MMIMSR), Maharishi Markandeshwar University (MMU), Mullana, Ambala 133207, Haryana, India
Anil Pawar
Department of Zoology, DAV University, Jalandhar 144012, Punjab, India
Mario Picozza
Neuroimmunology Unit, IRCSS Fondazione Santa Lucia, 00143 Rome, Italy
Mauro Rongioletti
Department of Laboratory Medicine, Research and Development Division, San Giovanni Calibita Fatebenefratelli Hospital, Isola Tiberina, 00186 Rome, Italy
Rosanna Squitti
Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy
Evidence of copper’s (Cu) involvement in Alzheimer’s disease (AD) is available, but information on Cu involvement in microglia and astrocytes during the course of AD has yet to be structurally discussed. This review deals with this matter in an attempt to provide an updated discussion on the role of reactive glia challenged by excess labile Cu in a wide picture that embraces all the major processes identified as playing a role in toxicity induced by an imbalance of Cu in AD.
