Nature Communications (Sep 2020)

Modulating mechanical stability of heterodimerization between engineered orthogonal helical domains

  • Miao Yu,
  • Zhihai Zhao,
  • Zibo Chen,
  • Shimin Le,
  • Jie Yan

DOI
https://doi.org/10.1038/s41467-020-18323-w
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 12

Abstract

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Mechanically stable specific heterodimerization formed with reversible bonds are used as a molecular anchorage in single-molecule force spectroscopy studies with unique mechanical properties. Here authors develop a variety of heterodimerization molecular systems with a range of mechanical stability from a set of recently engineered helix-heterotetramers.