A defined syphilis vaccine candidate inhibits dissemination of Treponema pallidum subspecies pallidum

Karen V. Lithgow; Rebecca Hof; Charmaine Wetherell; Drew Phillips; Simon Houston; Caroline E. Cameron

doi:10.1038/ncomms14273

Nature Communications (Feb 2017)

A defined syphilis vaccine candidate inhibits dissemination of Treponema pallidum subspecies pallidum

Karen V. Lithgow,
Rebecca Hof,
Charmaine Wetherell,
Drew Phillips,
Simon Houston,
Caroline E. Cameron

Affiliations

Karen V. Lithgow: Department of Biochemistry and Microbiology, University of Victoria
Rebecca Hof: Department of Biochemistry and Microbiology, University of Victoria
Charmaine Wetherell: Department of Biochemistry and Microbiology, University of Victoria
Drew Phillips: Department of Biochemistry and Microbiology, University of Victoria
Simon Houston: Department of Biochemistry and Microbiology, University of Victoria
Caroline E. Cameron: Department of Biochemistry and Microbiology, University of Victoria

DOI: https://doi.org/10.1038/ncomms14273
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 10

Abstract

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There are no vaccines for the prevention of syphilis, a disease caused by the bacteriumTreponema pallidum subsp. pallidum. Here, the authors use an animal model of infection to show that immunization with the Tp0751 bacterial protein inhibits the pathogen’s spread within the body.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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