Research progress in hypothermia-induced RBM3 in ischemia-reperfusion injury of various organs

Abstract

Ischemia-reperfusion injury （IRI） is a complex hemodynamic disorder with high mortality rates and limited treatment options. Mild hypothermia is a widely-accepted treatment method for alleviating ischemic and hypoxic injury， especially in the study of brain protection. Many studies have shown that RNA-binding motif protein 3 （RBM3）， as a cold stress protein， is mainly produced under low-temperature induction， which can promote translation， alleviate oxidative stress， and reduce cell mortality. Therefore， inducing RBM3 may represent a new strategy for treating IRI， replacing mild hypothermia and mitigating the side effects of hypothermia on the body. In this study， the latest findings on the function of RBM3 protein were summarized， highlighting the protective role and future prospect of RBM3 in IRI-related diseases of various organs.

Keywords

• hypothermia|rna-binding motif protein 3|brain ischemia-reperfusion injury|heart ischemia-reperfusion injury|liver ischemia-reperfusion injury|renal ischemia-reperfusion injury