Frontiers in Psychiatry (May 2020)
Age-Related Changes of Peak Width Skeletonized Mean Diffusivity (PSMD) Across the Adult Lifespan: A Multi-Cohort Study
- Grégory Beaudet,
- Grégory Beaudet,
- Ami Tsuchida,
- Ami Tsuchida,
- Laurent Petit,
- Laurent Petit,
- Christophe Tzourio,
- Svenja Caspers,
- Svenja Caspers,
- Jan Schreiber,
- Zdenka Pausova,
- Zdenka Pausova,
- Yash Patel,
- Yash Patel,
- Tomas Paus,
- Tomas Paus,
- Reinhold Schmidt,
- Lukas Pirpamer,
- Perminder S. Sachdev,
- Perminder S. Sachdev,
- Henry Brodaty,
- Henry Brodaty,
- Nicole Kochan,
- Nicole Kochan,
- Julian Trollor,
- Julian Trollor,
- Wei Wen,
- Wei Wen,
- Nicola J. Armstrong,
- Ian J. Deary,
- Mark E. Bastin,
- Mark E. Bastin,
- Joanna M. Wardlaw,
- Joanna M. Wardlaw,
- Susana Munõz Maniega,
- Susana Munõz Maniega,
- A. Veronica Witte,
- Arno Villringer,
- Marco Duering,
- Stéphanie Debette,
- Stéphanie Debette,
- Stéphanie Debette,
- Bernard Mazoyer,
- Bernard Mazoyer
Affiliations
- Grégory Beaudet
- Institute of Neurodegenerative Diseases (IMN), CNRS, CEA, Bordeaux, France
- Grégory Beaudet
- Institute of Neurodegenerative Diseases (IMN), University of Bordeaux, Bordeaux, France
- Ami Tsuchida
- Institute of Neurodegenerative Diseases (IMN), CNRS, CEA, Bordeaux, France
- Ami Tsuchida
- Institute of Neurodegenerative Diseases (IMN), University of Bordeaux, Bordeaux, France
- Laurent Petit
- Institute of Neurodegenerative Diseases (IMN), CNRS, CEA, Bordeaux, France
- Laurent Petit
- Institute of Neurodegenerative Diseases (IMN), University of Bordeaux, Bordeaux, France
- Christophe Tzourio
- Bordeaux Population Health Research Center, Inserm, Bordeaux, France
- Svenja Caspers
- Institute of Neuroscience and Medicine (INM-1), Research Centre Juelich, Juelich, Germany
- Svenja Caspers
- Institute for Anatomy I, Medical Faculty, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
- Jan Schreiber
- Institute of Neuroscience and Medicine (INM-1), Research Centre Juelich, Juelich, Germany
- Zdenka Pausova
- Research Institute, The Hospital for Sick Children, Toronto, ON, Canada
- Zdenka Pausova
- Department of Physiology and Nutritional Sciences, University of Toronto, Toronto, ON, Canada
- Yash Patel
- Research Institute, The Hospital for Sick Children, Toronto, ON, Canada
- Yash Patel
- Department of Physiology and Nutritional Sciences, University of Toronto, Toronto, ON, Canada
- Tomas Paus
- Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, ON, Canada
- Tomas Paus
- Departments of Psychology and Psychiatry, University of Toronto, Toronto, ON, Canada
- Reinhold Schmidt
- 0Department of Neurology, Medical University of Graz, Graz, Austria
- Lukas Pirpamer
- 0Department of Neurology, Medical University of Graz, Graz, Austria
- Perminder S. Sachdev
- 1Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney, NSW, Australia
- Perminder S. Sachdev
- 2Neuropsychiatric Institute, Neuropsychiatric Institute Prince of Wales Hospital, Randwick, NSW, Australia
- Henry Brodaty
- 1Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney, NSW, Australia
- Henry Brodaty
- 2Neuropsychiatric Institute, Neuropsychiatric Institute Prince of Wales Hospital, Randwick, NSW, Australia
- Nicole Kochan
- 1Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney, NSW, Australia
- Nicole Kochan
- 2Neuropsychiatric Institute, Neuropsychiatric Institute Prince of Wales Hospital, Randwick, NSW, Australia
- Julian Trollor
- 1Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney, NSW, Australia
- Julian Trollor
- 2Neuropsychiatric Institute, Neuropsychiatric Institute Prince of Wales Hospital, Randwick, NSW, Australia
- Wei Wen
- 1Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney, NSW, Australia
- Wei Wen
- 2Neuropsychiatric Institute, Neuropsychiatric Institute Prince of Wales Hospital, Randwick, NSW, Australia
- Nicola J. Armstrong
- 3Mathematics and Statistics, Murdoch University, Perth, WA, Australia
- Ian J. Deary
- 4Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom
- Mark E. Bastin
- 4Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom
- Mark E. Bastin
- 5Brain Research Imaging Centre, Neuroimaging Sciences, The University of Edinburgh, Edinburgh, United Kingdom
- Joanna M. Wardlaw
- 4Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom
- Joanna M. Wardlaw
- 5Brain Research Imaging Centre, Neuroimaging Sciences, The University of Edinburgh, Edinburgh, United Kingdom
- Susana Munõz Maniega
- 4Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom
- Susana Munõz Maniega
- 5Brain Research Imaging Centre, Neuroimaging Sciences, The University of Edinburgh, Edinburgh, United Kingdom
- A. Veronica Witte
- 6Departmet of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
- Arno Villringer
- 6Departmet of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
- Marco Duering
- 7Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany
- Stéphanie Debette
- Institute of Neurodegenerative Diseases (IMN), University of Bordeaux, Bordeaux, France
- Stéphanie Debette
- Bordeaux Population Health Research Center, Inserm, Bordeaux, France
- Stéphanie Debette
- 8Department of Neurology, Bordeaux University Hospital, Bordeaux, France
- Bernard Mazoyer
- Institute of Neurodegenerative Diseases (IMN), CNRS, CEA, Bordeaux, France
- Bernard Mazoyer
- Institute of Neurodegenerative Diseases (IMN), University of Bordeaux, Bordeaux, France
- DOI
- https://doi.org/10.3389/fpsyt.2020.00342
- Journal volume & issue
-
Vol. 11
Abstract
Parameters of water diffusion in white matter derived from diffusion-weighted imaging (DWI), such as fractional anisotropy (FA), mean, axial, and radial diffusivity (MD, AD, and RD), and more recently, peak width of skeletonized mean diffusivity (PSMD), have been proposed as potential markers of normal and pathological brain ageing. However, their relative evolution over the entire adult lifespan in healthy individuals remains partly unknown during early and late adulthood, and particularly for the PSMD index. Here, we gathered and analyzed cross-sectional diffusion tensor imaging (DTI) data from 10 population-based cohort studies in order to establish the time course of white matter water diffusion phenotypes from post-adolescence to late adulthood. DTI data were obtained from a total of 20,005 individuals aged 18.1 to 92.6 years and analyzed with the same pipeline for computing skeletonized DTI metrics from DTI maps. For each individual, MD, AD, RD, and FA mean values were computed over their FA volume skeleton, PSMD being calculated as the 90% peak width of the MD values distribution across the FA skeleton. Mean values of each DTI metric were found to strongly vary across cohorts, most likely due to major differences in DWI acquisition protocols as well as pre-processing and DTI model fitting. However, age effects on each DTI metric were found to be highly consistent across cohorts. RD, MD, and AD variations with age exhibited the same U-shape pattern, first slowly decreasing during post-adolescence until the age of 30, 40, and 50 years, respectively, then progressively increasing until late life. FA showed a reverse profile, initially increasing then continuously decreasing, slowly until the 70s, then sharply declining thereafter. By contrast, PSMD constantly increased, first slowly until the 60s, then more sharply. These results demonstrate that, in the general population, age affects PSMD in a manner different from that of other DTI metrics. The constant increase in PSMD throughout the entire adult life, including during post-adolescence, indicates that PSMD could be an early marker of the ageing process.
Keywords