Prognostic value of platelet distribution width to lymphocyte ratio in patients with hepatocellular carcinoma following hepatectomy
Zhi-Han Zhong,
Lei Liang,
Tian-Wei Fu,
Mu-Gen Dai,
Jian Cheng,
Si-Yu Liu,
Tai-Wei Ye,
Guo-Liang Shen,
Cheng-Wu Zhang,
Dong-Sheng Huang,
Jun-Wei Liu
Affiliations
Zhi-Han Zhong
General Surgery, Cancer Center, Department of Hepatobiliary & Pancreatic Surgery and Minimally Invasive Surgery, Affiliated People’s Hospital, Zhejiang Provincial People’s Hospital, Hangzhou Medical College
Lei Liang
General Surgery, Cancer Center, Department of Hepatobiliary & Pancreatic Surgery and Minimally Invasive Surgery, Affiliated People’s Hospital, Zhejiang Provincial People’s Hospital, Hangzhou Medical College
Tian-Wei Fu
General Surgery, Cancer Center, Department of Hepatobiliary & Pancreatic Surgery and Minimally Invasive Surgery, Affiliated People’s Hospital, Zhejiang Provincial People’s Hospital, Hangzhou Medical College
Mu-Gen Dai
Department of Gastroenterology, The Fifth Affiliated Hospital of Wenzhou Medical University
Jian Cheng
General Surgery, Cancer Center, Department of Hepatobiliary & Pancreatic Surgery and Minimally Invasive Surgery, Affiliated People’s Hospital, Zhejiang Provincial People’s Hospital, Hangzhou Medical College
Si-Yu Liu
Department of Laboratory Medicine, The Key Laboratory of Imaging Diagnosis and Minimally Invasive Interventional Research of Zhejiang Province, Zhejiang University Lishui Hospital
Tai-Wei Ye
General Surgery, Cancer Center, Department of Hepatobiliary & Pancreatic Surgery and Minimally Invasive Surgery, Affiliated People’s Hospital, Zhejiang Provincial People’s Hospital, Hangzhou Medical College
Guo-Liang Shen
General Surgery, Cancer Center, Department of Hepatobiliary & Pancreatic Surgery and Minimally Invasive Surgery, Affiliated People’s Hospital, Zhejiang Provincial People’s Hospital, Hangzhou Medical College
Cheng-Wu Zhang
General Surgery, Cancer Center, Department of Hepatobiliary & Pancreatic Surgery and Minimally Invasive Surgery, Affiliated People’s Hospital, Zhejiang Provincial People’s Hospital, Hangzhou Medical College
Dong-Sheng Huang
General Surgery, Cancer Center, Department of Hepatobiliary & Pancreatic Surgery and Minimally Invasive Surgery, Affiliated People’s Hospital, Zhejiang Provincial People’s Hospital, Hangzhou Medical College
Jun-Wei Liu
General Surgery, Cancer Center, Department of Hepatobiliary & Pancreatic Surgery and Minimally Invasive Surgery, Affiliated People’s Hospital, Zhejiang Provincial People’s Hospital, Hangzhou Medical College
Abstract Background Platelet distribution width (PDW), but not platelet count, was found to more comprehensively reflect platelet activity. The present study, thus, aimed to evaluate the prognostic value of PDW to lymphocyte ratio (PDWLR) in patients with hepatocellular carcinoma (HCC) following hepatectomy. Methods Patients following hepatectomy were analyzed retrospectively. The Kaplan-Meier survival curves and Cox regression model were used to determine the prognostic value of PDWLR. Results 241 patients were analyzed eventually, and stratified into low and high PDWLR groups (≤ 9.66 vs. > 9.66). Results of comparing the baseline characteristics showed that high PDWLR was significantly associated with cirrhosis, and intraoperative blood loss (all P < 0.05). In multivariate COX regression analysis, PDWLR was demonstrated as an independent risk factor for OS (HR: 1.549, P = 0.041) and RFS (HR: 1.655, P = 0.005). Moreover, PDWLR demonstrated a superior capacity for predicting prognosis compared to other indicators. Conclusion Preoperative PDWLR has a potential value in predicting the prognosis of HCC patients following hepatectomy, which may help in clinical decision-making for individual treatment.
