Rifampin phosphotransferase is an unusual antibiotic resistance kinase

Peter J. Stogios; Georgina Cox; Peter Spanogiannopoulos; Monica C. Pillon; Nicholas Waglechner; Tatiana Skarina; Kalinka Koteva; Alba Guarné; Alexei Savchenko; Gerard D. Wright

doi:10.1038/ncomms11343

Nature Communications (Apr 2016)

Rifampin phosphotransferase is an unusual antibiotic resistance kinase

Peter J. Stogios,
Georgina Cox,
Peter Spanogiannopoulos,
Monica C. Pillon,
Nicholas Waglechner,
Tatiana Skarina,
Kalinka Koteva,
Alba Guarné,
Alexei Savchenko,
Gerard D. Wright

Affiliations

Peter J. Stogios: Department of Chemical Engineering and Applied Chemistry, University of Toronto
Georgina Cox: Department of Biochemistry and Biomedical Sciences, M.G. DeGroote Institute for Infectious Disease Research, McMaster University
Peter Spanogiannopoulos: Department of Biochemistry and Biomedical Sciences, M.G. DeGroote Institute for Infectious Disease Research, McMaster University
Monica C. Pillon: Department of Biochemistry and Biomedical Sciences, McMaster University
Nicholas Waglechner: Department of Biochemistry and Biomedical Sciences, M.G. DeGroote Institute for Infectious Disease Research, McMaster University
Tatiana Skarina: Department of Biochemistry and Biomedical Sciences, M.G. DeGroote Institute for Infectious Disease Research, McMaster University
Kalinka Koteva: Department of Biochemistry and Biomedical Sciences, M.G. DeGroote Institute for Infectious Disease Research, McMaster University
Alba Guarné: Department of Biochemistry and Biomedical Sciences, McMaster University
Alexei Savchenko: Department of Chemical Engineering and Applied Chemistry, University of Toronto
Gerard D. Wright: Department of Biochemistry and Biomedical Sciences, M.G. DeGroote Institute for Infectious Disease Research, McMaster University

DOI: https://doi.org/10.1038/ncomms11343
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 12

Abstract

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Antibiotic resistance is a major clinical problem that threatens to undermine our ability to control infectious diseases. Here the authors present detailed structural analysis of Rifampin phosphotransferase from Listeria monocytogenes, yielding insight on how this class of enzyme inactivates its target antibiotics.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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