A comprehensive characterization of PncA polymorphisms that confer resistance to pyrazinamide

Adam N. Yadon; Kashmeel Maharaj; John H. Adamson; Yi-Pin Lai; James C. Sacchettini; Thomas R. Ioerger; Eric J. Rubin; Alexander S. Pym

doi:10.1038/s41467-017-00721-2

Nature Communications (Sep 2017)

A comprehensive characterization of PncA polymorphisms that confer resistance to pyrazinamide

Adam N. Yadon,
Kashmeel Maharaj,
John H. Adamson,
Yi-Pin Lai,
James C. Sacchettini,
Thomas R. Ioerger,
Eric J. Rubin,
Alexander S. Pym

Affiliations

Adam N. Yadon: Department of Immunology and Infectious Disease, Harvard T.H. Chan School of Public Health
Kashmeel Maharaj: African Health Research Institute (AHRI), Nelson R. Mandela School of Medicine
John H. Adamson: African Health Research Institute (AHRI), Nelson R. Mandela School of Medicine
Yi-Pin Lai: Department of Computer Science and Engineering, 3112 Texas A&M University
James C. Sacchettini: Department of Biochemistry and Biophysics, Texas A&M University
Thomas R. Ioerger: Department of Computer Science and Engineering, 3112 Texas A&M University
Eric J. Rubin: Department of Immunology and Infectious Disease, Harvard T.H. Chan School of Public Health
Alexander S. Pym: African Health Research Institute (AHRI), Nelson R. Mandela School of Medicine

DOI: https://doi.org/10.1038/s41467-017-00721-2
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 10

Abstract

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The antibiotic pyrazinamide is central to tuberculosis treatment regimens, globally. Despite its efficacy, resistance to the drug is increasing. Here, Eric Rubin and colleagues characterise the genetic basis of pyrazinamide resistance.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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