Relationships Among Gut Microbiota, Ischemic Stroke and Its Risk Factors: Based on Research Evidence

Abstract

Qinhong Huang,1 Guannan Cai,1 Ting Liu,2 Zhihua Liu3 1First Clinical School, Guangzhou Medical University, Guangzhou, 511436, People’s Republic of China; 2Guangzhou Key Laboratory of Enhanced Recovery after Abdominal Surgery, Innovation Center for Advanced Interdisciplinary Medicine, the Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510700, People’s Republic of China; 3Department of Anorectal Surgery, the Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510700, People’s Republic of ChinaCorrespondence: Ting Liu; Zhihua Liu, Email [email protected]; [email protected]: Stroke is a highly lethal disease and disabling illness while ischemic stroke accounts for the majority of stroke. It has been found that inflammation plays a key role in the initiation and progression of stroke, and atherosclerotic plaque rupture is considered to be the leading cause of ischemic stroke. Furthermore, chronic inflammatory diseases, such as obesity, type 2 diabetes mellitus (T2DM) and hypertension, are also considered as the high-risk factors for stroke. Recently, the topic on how gut microbiota affects human health has aroused great concern. The initiation and progression of ischemic stroke has been found to have close relation with gut microbiota dysbiosis. Hence, this manuscript briefly summarizes the roles of gut microbiota in ischemic stroke and its related risk factors, and the practicability of preventing and alleviating ischemic stroke by reconstructing gut microbiota.Keywords: ischemic stroke, gut microbiota, inflammation, obesity, T2DM, hypertension, type 2 diabetes mellitus

Keywords

• ischemic stroke
• gut microbiota
• inflammation
• obesity
• t2dm
• hypertension