Adaptation Effect of Repeated Xenon Application

Abstract

Objective: to investigate the effect of xenon addition to oxygen mixtures.Materials and methods. The repeated use of a xenon-oxygen gas mixture containing 50% xenon, 40% oxygen, and 10% nitrogen versus an oxygen mixture containing 40% oxygen on behavioral parameters characterizing orientativeexploratory activity, stress, and anxiety in Wistar rats, as well as the level of free radical oxidation and urgent protection proteins was comparatively analyzed.Results. Repeated exposure to the hyperoxic mixture increases the level of anxiety in animals and enhances the intensity of free radical processes and the activity of liver antioxidant protection enzymes; incorporation of xenon into the oxygen gas mixture levels off the multiple action of hyperoxia.Conclusion. The findings are suggestive of the lower level of anxiety in animals and the adaptation effect of repeated application of xenon incorporated into oxygen mixtures.

Keywords

• xenon, oxygen, hyperoxia, stress, adaptation, behavior, wistar rats, hsps, free radical oxidation, antioxidant enzymes