Levofloxacin prophylaxis for pediatric leukemia patients: monitoring of outcomes for sustained benefit and consequences

Andrea L. Davis; Alexandra M. Stevens; Julienne Brackett; Lucila Marquez; Catherine E. Foster; Adriana Sarmiento Clemente; Hannah E. Sauer; Grant T. Stimes; Judith R. Campbell

doi:10.1017/ash.2024.81

Antimicrobial Stewardship & Healthcare Epidemiology (Jan 2024)

Levofloxacin prophylaxis for pediatric leukemia patients: monitoring of outcomes for sustained benefit and consequences

Andrea L. Davis,
Alexandra M. Stevens,
Julienne Brackett,
Lucila Marquez,
Catherine E. Foster,
Adriana Sarmiento Clemente,
Hannah E. Sauer,
Grant T. Stimes,
Judith R. Campbell

Affiliations

Andrea L. Davis: ORCiD; Department Infection Control and Prevention, Texas Children’s Hospital, Houston, TX, USA
Alexandra M. Stevens: ORCiD; Department of Pediatrics, Section of Hematology Oncology, Baylor College of Medicine, Houston, TX, USA Texas Children’s Cancer Center, Texas Children’s Hospital, Houston, TX, USA
Julienne Brackett: ORCiD; Department of Pediatrics, Section of Hematology Oncology, Baylor College of Medicine, Houston, TX, USA Texas Children’s Cancer Center, Texas Children’s Hospital, Houston, TX, USA
Lucila Marquez: Department Infection Control and Prevention, Texas Children’s Hospital, Houston, TX, USA Department of Pediatrics, Division of Infectious Diseases, Baylor College of Medicine, Houston, TX, USA
Catherine E. Foster: ORCiD; Department Infection Control and Prevention, Texas Children’s Hospital, Houston, TX, USA Department of Pediatrics, Division of Infectious Diseases, Baylor College of Medicine, Houston, TX, USA
Adriana Sarmiento Clemente: ORCiD; Department of Pediatrics, Division of Infectious Diseases, Arkansas Children’s Hospital, Little Rock, AR, USA
Hannah E. Sauer: Department of Global Pediatric Medicine, St. Jude Medical Center, Memphis, TN, USA
Grant T. Stimes: ORCiD; Department of Pharmacy, Texas Children’s Hospital, Houston, TX, USA
Judith R. Campbell: ORCiD; Department Infection Control and Prevention, Texas Children’s Hospital, Houston, TX, USA Department of Pediatrics, Division of Infectious Diseases, Baylor College of Medicine, Houston, TX, USA

DOI: https://doi.org/10.1017/ash.2024.81
Journal volume & issue: Vol. 4

Abstract

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Levofloxacin prophylaxis reduces bloodstream infections in neutropenic patients with acute myeloid leukemia or relapsed acute lymphoblastic leukemia. A retrospective, longitudinal cohort study compares incidence of bacteremia, multidrug-resistant organisms (MDRO), and Clostridioides difficile (CDI) between time periods of levofloxacin prophylaxis implementation. Benefits were sustained without increasing MDRO or CDI.

Published in Antimicrobial Stewardship & Healthcare Epidemiology

ISSN: 2732-494X (Online)
Publisher: Cambridge University Press
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Infectious and parasitic diseases; Medicine: Public aspects of medicine
Website: https://www.cambridge.org/core/journals/antimicrobial-stewardship-and-healthcare-epidemiology

About the journal