Pediatric Hematology Oncology Journal (Jun 2022)
Outcomes of COVID-19 in children with cancer – Report from the Indian Pediatric Oncology Group (InPOG) COVID-19 registry in India
- Revathi Raj,
- Ramya Uppuluri,
- Badira Parambil,
- Nidhi Dhariwal,
- Sidharth Totadri,
- Leni Grace Mathew,
- Venkatraman Radhakrishnan,
- Abhishek Charan,
- Satya Prakash Yadav,
- Amita Mahajan,
- Sangeeta Mudaliar,
- Ratna Sharma,
- Mamta Manglani,
- Gaurav Kharya,
- Nishant Verma,
- Ramandeep Arora,
- Niharendu Ghara,
- Reghu KS,
- Nita Radhakrishnan,
- Nisha Iyer,
- Priti Mehta,
- Amitabh Singh,
- Shivani Patel,
- Joseph John,
- Sunil Bhat,
- Shobha Badiger,
- Sirisharani Siddaiahgari,
- Shruti Kakkar,
- Julius Scott,
- Dhaarani Jayaraman,
- Arathi Srinivasan,
- Yamini Krishnan,
- Ngangbam Sonamani,
- Ruchira Misra,
- Vibha Bafna,
- Rachna Seth,
- Purvi Kadakia Kutty,
- Swati Kanakia,
- Vasudha Rao,
- Anand Prakash,
- Vandana Bharadwaj,
- Girish Chinnasamy
Affiliations
- Revathi Raj
- Apollo Hospitals, Chennai, India; Corresponding author.
- Ramya Uppuluri
- Apollo Hospitals, Chennai, India
- Badira Parambil
- Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, India
- Nidhi Dhariwal
- Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, India
- Sidharth Totadri
- Christian Medical College, Vellore, India
- Leni Grace Mathew
- Christian Medical College, Vellore, India
- Venkatraman Radhakrishnan
- Cancer Institute, Adyar, Chennai, India
- Abhishek Charan
- Cancer Institute, Adyar, Chennai, India
- Satya Prakash Yadav
- Medanta-The Medicity Hospital, New Delhi, India
- Amita Mahajan
- Indraprastha Apollo Hospitals, New Delhi, India
- Sangeeta Mudaliar
- Lokmanya Tilak Municipal General Hospital and Medical College, Mumbai, India
- Ratna Sharma
- Comprehensive Thalassemia Care Centre, Mumbai, India
- Mamta Manglani
- Comprehensive Thalassemia Care Centre, Mumbai, India
- Gaurav Kharya
- Indraprastha Apollo Hospitals, New Delhi, India
- Nishant Verma
- King George's Medical University, Lucknow, India
- Ramandeep Arora
- Max Super Speciality Hospital, New Delhi, India
- Niharendu Ghara
- Tata Medical Centre, Kolkata, India
- Reghu KS
- Tata Medical Centre, Kolkata, India
- Nita Radhakrishnan
- Post Graduate Institute of Child Health, Noida, India
- Nisha Iyer
- Asian Cancer Institute, Mumbai, India
- Priti Mehta
- S.L. Raheja Hospital, Mumbai, India
- Amitabh Singh
- Safdarjung Hospital, New Delhi, India
- Shivani Patel
- Sri Aurobindo Institute of Medical Sciences, Indore, India
- Joseph John
- Christian Medical College, Ludhiana, India
- Sunil Bhat
- Mazumdar Shaw Medical Center and Narayana Health City, Bengaluru, India
- Shobha Badiger
- Mazumdar Shaw Medical Center and Narayana Health City, Bengaluru, India
- Sirisharani Siddaiahgari
- Rainbow Children's Hospital, Hyderabad, India
- Shruti Kakkar
- Dayanand Medical College and Hospital, Ludhiana, India
- Julius Scott
- Sri Ramachandra Institute of Higher Education and Research, Chennai, India
- Dhaarani Jayaraman
- Sri Ramachandra Institute of Higher Education and Research, Chennai, India
- Arathi Srinivasan
- Kanchi Kamakoti CHILDS Trust Hospital, Chennai, India
- Yamini Krishnan
- MVR Cancer Centre and Research Institute, Calicut, India
- Ngangbam Sonamani
- Mother's Care Children Hospital and Research Centre, Manipur, India
- Ruchira Misra
- SRCC Children's Hospital, Mumbai, India
- Vibha Bafna
- Jehangir Hospital, Pune, India
- Rachna Seth
- All India Institute of Medical Sciences, New Delhi, India
- Purvi Kadakia Kutty
- Apollo Hospitals, Navi Mumbai, India
- Swati Kanakia
- SRCC Children's Hospital, Mumbai, India
- Vasudha Rao
- Cytecare Cancer Hospitals, Bengaluru, India
- Anand Prakash
- St John's Medical College, Bengaluru, India
- Vandana Bharadwaj
- St John's Medical College, Bengaluru, India
- Girish Chinnasamy
- Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, India
- Journal volume & issue
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Vol. 7,
no. 2
pp. 34 – 37
Abstract
Introduction: The clinical outcomes of COVID-19 infection in children with cancer have been variable worldwide. Therefore, we aimed to collect data from all regions in India through a national collaborative study and identify factors that cause mortality directly related to COVID-19 infection. Methods: Data was collected prospectively on children across India on cancer therapy and diagnosed with COVID-19 infections from 47 centers from April 2020 to October 2021. Information was recorded on the demographics, the number of children that required intervention, and the outcome of the infection. In addition, we analyzed the impact of the delta variant in 2021. Results: A total of 659 children were studied, of whom 64% were male and 36% were female. The data from the eastern region was sparse, and this was a collection bias. COVID-19 infection was predominantly seen in children less than five years. The delta variant had a higher impact in the southern region, and this was statistically significant. Of the 659 children, 30 children died (4.5%), however only 7 of the deaths were directly attributed to COVID-19 infection (1%). Conclusion: The study reports the largest nationally representative cohort of children with cancer and COVID-19 to date in India. We identified demographic and clinical factors associated with increased all-cause mortality in patients with cancer. Complete characterization of the cohort has provided further insights into the effects of COVID-19 on cancer outcomes. The low mortality allows us to recommend that specific cancer treatments be continued without delays in therapy.
