Nature Communications (Apr 2022)
Loss of vascular endothelial notch signaling promotes spontaneous formation of tertiary lymphoid structures
- Susanne Fleig,
- Tamar Kapanadze,
- Jeremiah Bernier-Latmani,
- Julia K. Lill,
- Tania Wyss,
- Jaba Gamrekelashvili,
- Dustin Kijas,
- Bin Liu,
- Anne M. Hüsing,
- Esther Bovay,
- Adan Chari Jirmo,
- Stephan Halle,
- Melanie Ricke-Hoch,
- Ralf H. Adams,
- Daniel R. Engel,
- Sibylle von Vietinghoff,
- Reinhold Förster,
- Denise Hilfiker-Kleiner,
- Hermann Haller,
- Tatiana V. Petrova,
- Florian P. Limbourg
Affiliations
- Susanne Fleig
- Vascular Medicine Research, Hannover Medical School
- Tamar Kapanadze
- Vascular Medicine Research, Hannover Medical School
- Jeremiah Bernier-Latmani
- Vascular and Tumor Biology Laboratory, Department of Oncology UNIL CHUV and Ludwig Institute for Cancer Research
- Julia K. Lill
- Department of Immunodynamics, Institute for Experimental Immunology and Imaging, Medical Research Centre, University Hospital Essen
- Tania Wyss
- Vascular and Tumor Biology Laboratory, Department of Oncology UNIL CHUV and Ludwig Institute for Cancer Research
- Jaba Gamrekelashvili
- Vascular Medicine Research, Hannover Medical School
- Dustin Kijas
- Vascular Medicine Research, Hannover Medical School
- Bin Liu
- Hannover Medical School, Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), Member of the German Center for Lung Research (DZL)
- Anne M. Hüsing
- Department of Nephrology and Hypertension, Hannover Medical School
- Esther Bovay
- Max-Planck-Institute for Molecular Biomedicine
- Adan Chari Jirmo
- Hannover Medical School, Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), Member of the German Center for Lung Research (DZL)
- Stephan Halle
- Institute of Immunology, Hannover Medical School
- Melanie Ricke-Hoch
- Department of Cardiology and Angiology, Hannover Medical School
- Ralf H. Adams
- Max-Planck-Institute for Molecular Biomedicine
- Daniel R. Engel
- Department of Immunodynamics, Institute for Experimental Immunology and Imaging, Medical Research Centre, University Hospital Essen
- Sibylle von Vietinghoff
- Department of Nephrology and Hypertension, Hannover Medical School
- Reinhold Förster
- Institute of Immunology, Hannover Medical School
- Denise Hilfiker-Kleiner
- Department of Cardiology and Angiology, Hannover Medical School
- Hermann Haller
- Department of Nephrology and Hypertension, Hannover Medical School
- Tatiana V. Petrova
- Vascular and Tumor Biology Laboratory, Department of Oncology UNIL CHUV and Ludwig Institute for Cancer Research
- Florian P. Limbourg
- Vascular Medicine Research, Hannover Medical School
- DOI
- https://doi.org/10.1038/s41467-022-29701-x
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
Loss of canonical Notch signaling in vascular endothelial cells induces spontaneous formation of proto-typical tertiary lymphoid structures in mouse kidney, liver and lungs, which form around central arteries that acquire a high endothelial cell signature
