World Journal of Traditional Chinese Medicine (Jan 2019)

Research progress on the intervening effects of active components of Chinese herbs on amyloid-beta-induced injury of neural cells

  • Hang-Xuan Wu,
  • Er-Wei Hao,
  • Zheng-Cai Du,
  • Jian-Feng Qin,
  • Wei Wei,
  • Xiang-Long Pan,
  • Jin-Ling Xie,
  • Xiao-Tao Hou,
  • Jia-Gang Deng

DOI
https://doi.org/10.4103/wjtcm.wjtcm_11_19
Journal volume & issue
Vol. 5, no. 2
pp. 122 – 130

Abstract

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Alzheimer's disease is a common clinical central nervous system degenerative disease. From 1906, it has not yet been clearly revealed the pathogenesis, and there are no clinically safe and effective drugs. Amyloid-beta (Aβ) cascade reaction theory is currently recognized as the pathogenesis. Aβ deposition of neurotoxicity is an important part of the pathogenesis. There are Aβ-induced inflammation of the central nervous and oxidative stress-induced apoptosis induced by a variety of ways leading to neuronal dysfunction and death. This article summarizes the active ingredients of traditional Chinese medicine that has a protective effect on Aβ toxicity in recent years. Traditional Chinese medicine mainly through the antiapoptosis, antioxidation, and anti-inflammatory reduces Aβ production and deposition of Aβ on the protection of nerve cell injury.

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