Clonal origin and development of high hyperdiploidy in childhood acute lymphoblastic leukaemia

Eleanor L. Woodward; Minjun Yang; Larissa H. Moura-Castro; Hilda van den Bos; Rebeqa Gunnarsson; Linda Olsson-Arvidsson; Diana C. J. Spierings; Anders Castor; Nicolas Duployez; Marketa Zaliova; Jan Zuna; Bertil Johansson; Floris Foijer; Kajsa Paulsson

doi:10.1038/s41467-023-37356-5

Nature Communications (Mar 2023)

Clonal origin and development of high hyperdiploidy in childhood acute lymphoblastic leukaemia

Eleanor L. Woodward,
Minjun Yang,
Larissa H. Moura-Castro,
Hilda van den Bos,
Rebeqa Gunnarsson,
Linda Olsson-Arvidsson,
Diana C. J. Spierings,
Anders Castor,
Nicolas Duployez,
Marketa Zaliova,
Jan Zuna,
Bertil Johansson,
Floris Foijer,
Kajsa Paulsson

Affiliations

Eleanor L. Woodward: Department of Laboratory Medicine, Division of Clinical Genetics, Lund University
Minjun Yang: Department of Laboratory Medicine, Division of Clinical Genetics, Lund University
Larissa H. Moura-Castro: Department of Laboratory Medicine, Division of Clinical Genetics, Lund University
Hilda van den Bos: European Research Institute for the Biology of Ageing (ERIBA), University of Groningen, University Medical Center Groningen
Rebeqa Gunnarsson: Department of Laboratory Medicine, Division of Clinical Genetics, Lund University
Linda Olsson-Arvidsson: Department of Laboratory Medicine, Division of Clinical Genetics, Lund University
Diana C. J. Spierings: European Research Institute for the Biology of Ageing (ERIBA), University of Groningen, University Medical Center Groningen
Anders Castor: Department of Pediatrics, Skåne University Hospital, Lund University
Nicolas Duployez: Laboratory of Hematology, Centre Hospitalier Universitaire (CHU) Lille
Marketa Zaliova: Department of Pediatric Hematology and Oncology, Second Faculty of Medicine, Charles University/University Hospital Motol
Jan Zuna: Department of Pediatric Hematology and Oncology, Second Faculty of Medicine, Charles University/University Hospital Motol
Bertil Johansson: Department of Laboratory Medicine, Division of Clinical Genetics, Lund University
Floris Foijer: European Research Institute for the Biology of Ageing (ERIBA), University of Groningen, University Medical Center Groningen
Kajsa Paulsson: Department of Laboratory Medicine, Division of Clinical Genetics, Lund University

DOI: https://doi.org/10.1038/s41467-023-37356-5
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 14

Abstract

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High hyperdiploid acute lymphoblastic leukaemia (HeH ALL) is driven by nonrandom chromosomal gains, which have been suggested to arise early - even before birth. Here, the authors use single-cell whole genome sequencing and in silico modelling to show that HeH ALL aneuploidies could originate early and follow punctuated evolution.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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