Nature Communications (Apr 2018)

Direct binding of CEP85 to STIL ensures robust PLK4 activation and efficient centriole assembly

  • Yi Liu,
  • Gagan D. Gupta,
  • Deepak D. Barnabas,
  • Fikret G. Agircan,
  • Shahid Mehmood,
  • Di Wu,
  • Etienne Coyaud,
  • Christopher M. Johnson,
  • Stephen H. McLaughlin,
  • Antonina Andreeva,
  • Stefan M. V. Freund,
  • Carol V. Robinson,
  • Sally W. T. Cheung,
  • Brian Raught,
  • Laurence Pelletier,
  • Mark van Breugel

DOI
https://doi.org/10.1038/s41467-018-04122-x
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 15

Abstract

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Centriole duplication is tightly regulated in vivo, but the underlying molecular mechanisms are incompletely understood. Here the authors use high-resolution structural and imaging methods to show that CEP85 directly interacts with STIL and mediates efficient centriolar targeting of STIL, PLK4 activation and centriole assembly.