Sevoflurane-induced pica in female rats

Kouichi Yamamoto; Emiri Yamamoto; Toru Sugimoto; Takuya Sagakami; Atsushi Yamatodani

doi:10.1016/j.jphs.2016.03.015

Journal of Pharmacological Sciences (May 2016)

Sevoflurane-induced pica in female rats

Kouichi Yamamoto,
Emiri Yamamoto,
Toru Sugimoto,
Takuya Sagakami,
Atsushi Yamatodani

Affiliations

Kouichi Yamamoto: Department of Medical Science and Technology, Division of Health Sciences, Graduate School of Medicine, Osaka University, 1-7 Yamadaoka, Suita, Osaka 565-0871, Japan
Emiri Yamamoto: Department of Anesthesiology, Kaizuka City Hospital, 3-10-20 Hori, Kaizuka, Osaka 597-0015, Japan
Toru Sugimoto: Department of Medical Science and Technology, Division of Health Sciences, Graduate School of Medicine, Osaka University, 1-7 Yamadaoka, Suita, Osaka 565-0871, Japan
Takuya Sagakami: Department of Medical Science and Technology, Division of Health Sciences, Graduate School of Medicine, Osaka University, 1-7 Yamadaoka, Suita, Osaka 565-0871, Japan
Atsushi Yamatodani: Osaka University, 1-7 Yamadaoka, Suita, Osaka 565-0871, Japan

DOI: https://doi.org/10.1016/j.jphs.2016.03.015
Journal volume & issue: Vol. 131, no. 1
pp. 68 – 71

Abstract

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We examined the effects of volatile anesthetics on pica, which can be used to assess nausea and vomiting in rats. We found that inhalation anesthesia with sevoflurane significantly induced pica in female but not male rats. Among the female rats, young rats (8 weeks old) were more susceptible to its induction than adult rats (20 weeks old) with ovariectomy or sham-surgery. Anti-emetic drugs that are used to prevent postoperative nausea and vomiting (PONV) inhibited the pica. These results suggest that sevoflurane-induced pica in young female rats has the potential to be an animal model of PONV in humans.

Published in Journal of Pharmacological Sciences

ISSN: 1347-8613 (Print)
Publisher: Elsevier
Country of publisher: Japan
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: http://www.journals.elsevier.com/journal-of-pharmacological-sciences

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