Creb5 coordinates synovial joint formation with the genesis of articular cartilage

Cheng-Hai Zhang; Yao Gao; Han-Hwa Hung; Zhu Zhuo; Alan J. Grodzinsky; Andrew B. Lassar

doi:10.1038/s41467-022-35010-0

Nature Communications (Nov 2022)

Creb5 coordinates synovial joint formation with the genesis of articular cartilage

Cheng-Hai Zhang,
Yao Gao,
Han-Hwa Hung,
Zhu Zhuo,
Alan J. Grodzinsky,
Andrew B. Lassar

Affiliations

Cheng-Hai Zhang: Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute at Harvard Medical School
Yao Gao: Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute at Harvard Medical School
Han-Hwa Hung: Department of Biological Engineering, Massachusetts Institute of Technology
Zhu Zhuo: Bioinformatics Core, Department of Biostatistics, Harvard T.H. Chan School of Public Health
Alan J. Grodzinsky: Department of Biological Engineering, Massachusetts Institute of Technology
Andrew B. Lassar: Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute at Harvard Medical School

DOI: https://doi.org/10.1038/s41467-022-35010-0
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 18

Abstract

Read online

Zhang et al. show that the Creb5 transcription factor regulates the formation of synovial joints, directs the genesis of articular cartilage, and regulates the shape of the ends of long bones by blocking Wnt5a expression in the perichondrium.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal