Synthesis of an ent-Halimanolide from ent-Halimic Acid

Abstract

An efficient synthesis of ent-halimanolide 2 (15,16-epoxy-12-oxo-ent-halima- 5(10),13(16),14-trien-18,2β-olide), from ent-halimic acid has been achieved, corroborating the structure of the natural compound and establishing its absolute configuration.

Keywords

• Ent-halimanolides
• ent-halimic acid
• diterpenoids
• Cladogynos orientalis.