Advances and innovations of hybrid nanofiber-based matrices for dental-tissue engineering

Abstract

Although traditional dental-implant approaches have served as primary solutions, they are limited by infection risks, complications, and prolonged failures. Hybrid electrospun nanofiber matrices based on biomaterials have emerged as compelling alternatives for dental-tissue regeneration, offering direct cell-matrix contact and facile modification to incorporate anti-inflammatory, angiogenic, antimicrobial, and osteogenic properties. In this review, we discuss the advancements in hybrid nanofiber matrix-based approaches in dental-tissue engineering over the past five years (2019–2023). Beginning with an exploration of dental tissues and tooth structures, we discuss the innovative strategies in each study, including fabrication methods, physicochemical and biological properties, and osteogenic potential. We anticipate that ongoing research will enable the widespread application of innovative biomaterials and nanofiber matrices in future dental therapies.

Keywords

• Nanofiber
• electrospinning
• dental-tissue engineering
• osteogenesis
• biomaterials