Guidelines from the 2017 European Conference on Infections in Leukaemia for management of HHV-6 infection in patients with hematologic malignancies and after hematopoietic stem cell transplantation
Katherine N Ward,
Joshua A Hill,
Petr Hubacek,
Rafael de la Camara,
Roberto Crocchiolo,
Hermann Einsele,
David Navarro,
Christine Robin,
Catherine Cordonnier,
Per Ljungman
Affiliations
Katherine N Ward
Division of Infection and Immunity, University College London, London, UK
Joshua A Hill
Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Petr Hubacek
Department of Medical Microbiology and Department of Paediatric Haematology and Oncology 2nd Medical Faculty of Charles University and Motol University Hospital, Prague, Czech Republic
Rafael de la Camara
Department of Haematology, Hospital de la Princesa, Madrid, Spain
Roberto Crocchiolo
SIMT, ASST di Bergamo Ovest, Treviglio, Italy
Hermann Einsele
Medizinische Klinik und Poliklinik II, Julius Maximilians Universität, Würzburg, Germany
David Navarro
Microbiology Service, Hospital Clínico Universitario, Instituto de Investigación INCLIVA and Department of Microbiology, School of Medicine, University of Valencia, Valencia, Spain
Christine Robin
Department of Haematology, Henri Mondor Hospital, Assistance Publique-Hopitaux de Paris, Université Paris-Est Créteil, Créteil, France
Catherine Cordonnier
Department of Haematology, Henri Mondor Hospital, Assistance Publique-Hopitaux de Paris, Université Paris-Est Créteil, Créteil, France
Per Ljungman
Department of Cellular Therapy and Allogeneic Stem Cell Transplantation, Karolinska University Hospital, Division of Haematology, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden
Of the two human herpesvirus 6 (HHV-6) species, human herpesvirus 6B (HHV-6B) encephalitis is an important cause of morbidity and mortality after allogeneic hematopoietic stem cell transplant. Guidelines for the management of HHV-6 infections in patients with hematologic malignancies or post-transplant were prepared a decade ago but there have been no other guidelines since then despite significant advances in the understanding of HHV-6 encephalitis, its therapy, and other aspects of HHV-6 disease in this patient population. Revised guidelines prepared at the 2017 European Conference on Infections in Leukaemia covering diagnosis, preventative strategies and management of HHV-6 disease are now presented.
