Nature Communications (Aug 2018)

Formal group insertion into aryl C‒N bonds through an aromaticity destruction-reconstruction process

  • Dandan Han,
  • Qiuqin He,
  • Renhua Fan

DOI
https://doi.org/10.1038/s41467-018-05637-z
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 7

Abstract

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Activation of C–N bonds of anilines requires transformation of the amino group into a more reactive functionality. Here, the authors report an aromaticity destruction-reconstruction process that converts abundant anilines into valuable amines through group insertion into the C–N bond and benzylic C–H functionalization.