SODIUMNITROPRUSSIDE AS A HYPOTENSIVE AGENT DURING GENERAL ANAESTHESIA AND PLASMA LEVEL OF NO

Abstract

The study included 30 patients who received general anaesthesia due to chronically inflammatory disease of the middle ear.The aim of the study was determination of plasma level of NO if we use sodium nitroprusside (SNP) as a hypotensive agent and the correlation between plasma level of NO and mean arterial pressure (MAP).Material: 30 patients were divided in two groups: 15 patients received general anaesthesia with continuous intravenous infusion of sodium nitroprusside as a hypotensive agent and 15 patients received general anaesthesia without hypotensive agent.The level of MAP during hypotensive anaesthesia was between 60 and 70 mmHg (8-9kPa).Method: enzymatic method according to Conrad.The results have shown that general anaesthesia with continuous intavenous infusion of SNP produces higher plasma level of NO than plasma level of NO in patients who received general anaesthesia without hypotensive agent. The type of correlation between NO and MAP is negative, which means that if the level of MAP decreases, the level of NO increases.

Keywords

• plasma level of NO
• sodium nitroprusside (SNP) hypotensive anaesthesia
• middle ear surgery