Antibody-controlled actuation of DNA-based molecular circuits

Wouter Engelen; Lenny H. H. Meijer; Bram Somers; Tom F. A. de Greef; Maarten Merkx

doi:10.1038/ncomms14473

Nature Communications (Feb 2017)

Antibody-controlled actuation of DNA-based molecular circuits

Wouter Engelen,
Lenny H. H. Meijer,
Bram Somers,
Tom F. A. de Greef,
Maarten Merkx

Affiliations

Wouter Engelen: Department of Biomedical Engineering, Laboratory of Chemical Biology and Institute of Complex Molecular Systems, Eindhoven University of Technology
Lenny H. H. Meijer: Department of Biomedical Engineering, Laboratory of Chemical Biology and Institute of Complex Molecular Systems, Eindhoven University of Technology
Bram Somers: Department of Biomedical Engineering, Laboratory of Chemical Biology and Institute of Complex Molecular Systems, Eindhoven University of Technology
Tom F. A. de Greef: Department of Biomedical Engineering, Laboratory of Chemical Biology and Institute of Complex Molecular Systems, Eindhoven University of Technology
Maarten Merkx: Department of Biomedical Engineering, Laboratory of Chemical Biology and Institute of Complex Molecular Systems, Eindhoven University of Technology

DOI: https://doi.org/10.1038/ncomms14473
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 8

Abstract

Read online

Existing DNA based circuits, designed to perform logic operations and signal processing, are generally responsive to DNA or RNA inputs. Here, the authors show that antibodies can actuate DNA logic gates, opening the way to applications of DNA computing in diagnostics and biomedicine.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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