Recent Developments in Magnetic Hyperthermia Therapy (MHT) and Magnetic Particle Imaging (MPI) in the Brain Tumor Field: A Scoping Review and Meta-Analysis
Frederika Rentzeperis,
Daniel Rivera,
Jack Y. Zhang,
Cole Brown,
Tirone Young,
Benjamin Rodriguez,
Alexander Schupper,
Gabrielle Price,
Jack Gomberg,
Tyree Williams,
Alexandros Bouras,
Constantinos Hadjipanayis
Affiliations
Frederika Rentzeperis
Department of Medical Education, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
Daniel Rivera
Department of Medical Education, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
Jack Y. Zhang
Department of Medical Education, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
Cole Brown
Department of Medical Education, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
Tirone Young
Department of Medical Education, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
Benjamin Rodriguez
Department of Medical Education, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
Alexander Schupper
Department of Neurological Surgery, Mount Sinai Hospital, New York, NY 10029, USA
Gabrielle Price
Department of Medical Education, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
Jack Gomberg
Department of Medical Education, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
Tyree Williams
Sinai BioDesign, Department of Neurosurgery, Mount Sinai, New York, NY 10029, USA
Alexandros Bouras
Brain Tumor Nanotechnology Laboratory, UPMC Hillman Cancer Center, Pittsburgh, PA 15232, USA
Constantinos Hadjipanayis
Brain Tumor Nanotechnology Laboratory, UPMC Hillman Cancer Center, Pittsburgh, PA 15232, USA
Magnetic hyperthermia therapy (MHT) is a promising treatment modality for brain tumors using magnetic nanoparticles (MNPs) locally delivered to the tumor and activated with an external alternating magnetic field (AMF) to generate antitumor effects through localized heating. Magnetic particle imaging (MPI) is an emerging technology offering strong signal-to-noise for nanoparticle localization. A scoping review was performed by systematically querying Pubmed, Scopus, and Embase. In total, 251 articles were returned, 12 included. Articles were analyzed for nanoparticle type used, MHT parameters, and MPI applications. Preliminary results show that MHT is an exciting treatment modality with unique advantages over current heat-based therapies for brain cancer. Effective application relies on the further development of unique magnetic nanoparticle constructs and imaging modalities, such as MPI, that can enable real-time MNP imaging for improved therapeutic outcomes.
