Eudesmane-Type Sesquiterpene Glycosides from Dictamnus dasycarpus Turcz.

Abstract

Eudesmane-type sesquiterpenes have been reported to exhibit varieties of biological activities. During the process of investigating this kind of natural product from the root bark of Dictamnus dasycarpus Turcz., 13 eudesmane-type sesquiterpene glycosides including six new isolates, named as dictameudesmnosides A1 (1), A2 (2), B (3), C (4), D (5), and E (6), together with seven known ones (7–13), were obtained. Herein, their structures were determined by the analysis of physical data, spectroscopic analysis, and chemical methods. The existence of α-configuration glucose units in their structures (1–5, 8) is not very common in natural glycosidic components. Meanwhile, compounds 3–5, 7, and 9–13 displayed TG accumulation inhibitory effects on HepG2 cells.

Keywords

• Dictamnus dasycarpus Turcz.
• sesquiterpene glycoside
• eudesmane-type sesquiterpene
• dictameudesmnoside
• triglyceride accumulation
• HepG2 cell