Autofluorescence and diffuse reflectance spectroscopic analysis of oral premalignancy and malignancy

Abstract

Early detection of squamous cell carcinoma in the oral cavity can improve survival. It is often difficult to distinguish neoplastic and premalignant disorders with standard white light illumination. Fast and noninvasive, diagnostic techniques based on fluorescence spectroscopy have the potential to link the biochemical and morphologic properties of tissues to individual patient care. In this study comparison between malignant, premalignant and healthy mucosa groups was done based on autofluorescence and diffuse reflectance spectroscopic analysis. Fluorescence spectroscopy is a new diagnostic modality with the potential to bridge the gap between clinical examination and invasive biopsy.

Keywords

• Autofluorescence
• malignancy
• oral premalignancy