Synthesis and Pharmacological Activities of Some New Triazolo- and Tetrazolopyrimidine Derivatives
Saleh A. Bahashwan,
Ahmed A. Fayed,
Abd El-Galil E. Amr,
Eman M. Flefel,
Atef Kalmouch
Affiliations
Saleh A. Bahashwan
Pharmacology and Toxicology Department, College of Pharmacy, Taibah University, Al-Madinah Al-Munawara 3893, Saudi Arabia
Ahmed A. Fayed
Respiratory Department (Applied Organic & Biochemistry Division), College of Medical Rehabilitation Sciences, Taibah University, Al-Madinah Al-Munawara 3893, Saudi Arabia
Abd El-Galil E. Amr
National Research Center, Dokki, Cairo, Dokki 12622, Egypt
Eman M. Flefel
National Research Center, Dokki, Cairo, Dokki 12622, Egypt
Atef Kalmouch
National Research Center, Dokki, Cairo, Dokki 12622, Egypt
A new series of fused triazolo- and tetrazolopyrimidine derivatives 2–14 were synthesized and their anti-inflammatory and ulcerogenic activities were evaluated. The pharmacological screening showed that many of these obtained compounds have good anti-inflammatory activities, comparable to the reference drug. The toxicity of the compounds was also assayed via the determination of their LD50 values. The structures of newly synthesized compounds were confirmed by IR, 1H-NMR, MS spectral data and elemental analysis.
