Obesity is a risk factor for iron metabolism disorder

Abstract

There is data on the pathogenetic links between iron deficiency and systemic inflammation associated with obesity. In chronic inflammation in obese patients, a mechanism of iron sequestration becomes activated primarily by macrophage and adipose tissue cells. The efficiency of iron absorption from food, its uptake by erythroid cells and heme synthesis are decreased. Excessive accumulation of iron in fat cells induces oxidative and endoplasmic stress and production of proinflammatory cytokines, thus affecting the key pathogenetic links of obesity and exacerbating the condition. There is clinical evidence suggesting better iron metabolism parameters and decreased serum hepcidin in patients who lost weight after bariatric surgery. The findings related to the incidence and pathogenic form of anemia (iron deficiency or anemia of chronic disease) after bariatric surgery are heterogenous.

Keywords

• ожирение
• дефицит железа
• ферритин
• хроническое воспаление
• гепсидин
• анемия
• бариатрические операции
• obesity
• iron deficiency
• ferritin
• chronic inflammation
• hepcidin
• anemia
• bariatric surgery