Nature Communications (Mar 2018)

An evolutionary hotspot defines functional differences between CRYPTOCHROMES

  • Clark Rosensweig,
  • Kimberly A. Reynolds,
  • Peng Gao,
  • Isara Laothamatas,
  • Yongli Shan,
  • Rama Ranganathan,
  • Joseph S. Takahashi,
  • Carla B. Green

DOI
https://doi.org/10.1038/s41467-018-03503-6
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 15

Abstract

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The molecular mechanisms that define the periodicity or rate of the circadian clock are not well understood. Here the authors use a multidisciplinary approach and identify a mechanism for period regulation that depends on the affinity of the core clock proteins for one another.