Novel Local Antifungal Treatment for Fungal Periprosthetic Joint Infection With Continuous Local Antibiotic Perfusion: A Surgical Technique

Hyonmin Choe, MD, PhD; Akihiro Maruo, MD, PhD; Yuta Hieda, MD; Koki Abe, MD, PhD; Naomi Kobayashi, MD, PhD; Hiroyuki Ike, MD, PhD; Ken Kumagai, MD, PhD; Masanobu Takeyama, MD, PhD; Yusuke Kawabata, MD, PhD; Yutaka Inaba, MD, PhD

Arthroplasty Today (Dec 2023)

Novel Local Antifungal Treatment for Fungal Periprosthetic Joint Infection With Continuous Local Antibiotic Perfusion: A Surgical Technique

Hyonmin Choe, MD, PhD,
Akihiro Maruo, MD, PhD,
Yuta Hieda, MD,
Koki Abe, MD, PhD,
Naomi Kobayashi, MD, PhD,
Hiroyuki Ike, MD, PhD,
Ken Kumagai, MD, PhD,
Masanobu Takeyama, MD, PhD,
Yusuke Kawabata, MD, PhD,
Yutaka Inaba, MD, PhD

Affiliations

Hyonmin Choe, MD, PhD: Department of Orthopaedic Surgery, Yokohama City University, Yokohama, Kanagawa, Japan; Corresponding author. Department of Orthopaedic Surgery, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, 231-0004, Japan. Tel.: +81 045 787 2655.
Akihiro Maruo, MD, PhD: Department of Orthopaedic Surgery, Harima Himeji General Medical Center, Himeji, Japan
Yuta Hieda, MD: Department of Orthopaedic Surgery, Yokohama City University, Yokohama, Kanagawa, Japan
Koki Abe, MD, PhD: Department of Orthopaedic Surgery, Yokohama City University, Yokohama, Kanagawa, Japan
Naomi Kobayashi, MD, PhD: Department of Orthopaedic Surgery, Yokohama City University Medical Center, Yokohama, Kanagawa, Japan
Hiroyuki Ike, MD, PhD: Department of Orthopaedic Surgery, Yokohama City University, Yokohama, Kanagawa, Japan
Ken Kumagai, MD, PhD: Department of Orthopaedic Surgery, Yokohama City University, Yokohama, Kanagawa, Japan
Masanobu Takeyama, MD, PhD: Department of Orthopaedic Surgery, Yokohama City University, Yokohama, Kanagawa, Japan
Yusuke Kawabata, MD, PhD: Department of Orthopaedic Surgery, Yokohama City University, Yokohama, Kanagawa, Japan
Yutaka Inaba, MD, PhD: Department of Orthopaedic Surgery, Yokohama City University, Yokohama, Kanagawa, Japan

Journal volume & issue: Vol. 24
p. 101245

Abstract

Read online

Fungal periprosthetic joint infections are one of the most intractable orthopedic disorders. Continuous local antibiotic perfusion allows direct administration of the antifungal agent micafungin into the local infection area at biofilm-disruptive concentrations, while controlling the dead space in addition to conventional treatment. Although the appropriate use of continuous local antibiotic perfusion requires familiarity with the characteristics of local antibiotic perfusion, it is a versatile treatment modality that can improve the clinical outcomes of fungal periprosthetic joint infection in combination with conventional treatment methods.

Published in Arthroplasty Today

ISSN: 2352-3441 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Surgery: Orthopedic surgery
Website: https://www.journals.elsevier.com/arthroplasty-today/

About the journal

Abstract

Keywords