Nature Communications (Apr 2018)

ATAC-Seq analysis reveals a widespread decrease of chromatin accessibility in age-related macular degeneration

  • Jie Wang,
  • Cristina Zibetti,
  • Peng Shang,
  • Srinivasa R. Sripathi,
  • Pingwu Zhang,
  • Marisol Cano,
  • Thanh Hoang,
  • Shuli Xia,
  • Hongkai Ji,
  • Shannath L. Merbs,
  • Donald J. Zack,
  • James T. Handa,
  • Debasish Sinha,
  • Seth Blackshaw,
  • Jiang Qian

DOI
https://doi.org/10.1038/s41467-018-03856-y
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 13

Abstract

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Age-related macular degeneration (AMD) leads to dysfunctional retinal pigment epithelium (RPE) and vision loss. Here, the authors perform ATAC-seq to study chromatin accessibility and find that differentially accessible regions are enriched for photoreceptor and RPE-specific transcription factors in AMD