Nature Communications (Sep 2017)
Fas cell surface death receptor controls hepatic lipid metabolism by regulating mitochondrial function
- Flurin Item,
- Stephan Wueest,
- Vera Lemos,
- Sokrates Stein,
- Fabrizio C. Lucchini,
- Rémy Denzler,
- Muriel C. Fisser,
- Tenagne D. Challa,
- Eija Pirinen,
- Youngsoo Kim,
- Silvio Hemmi,
- Erich Gulbins,
- Atan Gross,
- Lorraine A. O’Reilly,
- Markus Stoffel,
- Johan Auwerx,
- Daniel Konrad
Affiliations
- Flurin Item
- Division of Pediatric Endocrinology and Diabetology, University Children’s Hospital
- Stephan Wueest
- Division of Pediatric Endocrinology and Diabetology, University Children’s Hospital
- Vera Lemos
- Metabolic Signaling, École Polytechnique Fédérale de Lausanne (EPFL)
- Sokrates Stein
- Metabolic Signaling, École Polytechnique Fédérale de Lausanne (EPFL)
- Fabrizio C. Lucchini
- Division of Pediatric Endocrinology and Diabetology, University Children’s Hospital
- Rémy Denzler
- Institute of Molecular Health Sciences, ETH Zurich
- Muriel C. Fisser
- Institute of Molecular Health Sciences, ETH Zurich
- Tenagne D. Challa
- Division of Pediatric Endocrinology and Diabetology, University Children’s Hospital
- Eija Pirinen
- Laboratory of Integrative and Systems Physiology (LISP), École Polytechnique Fédérale de Lausanne (EPFL)
- Youngsoo Kim
- Ionis Pharmaceuticals Inc.
- Silvio Hemmi
- Institute of Molecular Life Sciences, University of Zurich
- Erich Gulbins
- Department of Molecular Biology, University of Duisburg-Essen
- Atan Gross
- Department of Biological Regulation, The Weizmann Institute of Science
- Lorraine A. O’Reilly
- The Walter and Eliza Hall Institute of Medical Research
- Markus Stoffel
- Institute of Molecular Health Sciences, ETH Zurich
- Johan Auwerx
- Laboratory of Integrative and Systems Physiology (LISP), École Polytechnique Fédérale de Lausanne (EPFL)
- Daniel Konrad
- Division of Pediatric Endocrinology and Diabetology, University Children’s Hospital
- DOI
- https://doi.org/10.1038/s41467-017-00566-9
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 10
Abstract
Hepatic steatosis is a common disease closely associated with metabolic syndrome and insulin resistance. Here Item et al. show that Fas, a member of the TNF receptor superfamily, contributes to mitochondrial dysfunction, steatosis development, and insulin resistance under high fat diet.
