Neurogenic inflammation markers in children with vertebrobasilar arterial system syndrome and recurrent bronchitis

Abstract

Background. The study of the neurogenic maintenance characteristics of the recurrent bronchitis (RB) course in children with the vertebrobasilar arterial system syndrome (VBASS) by studying the levels of the final stable metabolites of nitric oxide (FSM NO), substance P and vasoactive intestinal peptide (VIP) will make it possible to establish important elements of the frequent diseases respiratory tract pathogenesis. Materials and methods. Sixty children aged 7 to 11 years old with anamnesis of RB were examined. Two observation groups were formed (30 patients in each): 1) children with RB in the period of somatic well-being and VBASS; 2) children with RB in the period of somatic well-being without VBASS. Results. In children with RB, who have VBASS, as compared to the children without VBASS, we have detected an increase in FSM NO serum levels (by 36.7 %, p < 0.05) (odds ratio (OR) = 6.50, 95% confidence interval (CI) 1.82–23.21, p < 0.05), substance P (by 40.0 %, p < 0.05) (OR = 6.00, 95% CI 1.89–19.04, p < 0.05), a decrease in concentration of VIP (by 26.7 %, p < 0.05) (OR = 3.05, 95% CI 1.05–8.84, p < 0.05) statistically significantly more often. Conclusions. In children with RB and VBASS, during the period of somatic well-being, the focus of the neurogenic inflammatory process takes place, which is accompanied by an autonomous neuronal processes imbalance and predisposition to recurrent bronchopulmonary pathology.

Keywords

• children
• bronchitis
• substance P
• vasoactive intestinal peptide
• nitric oxide