Study of Zn(II)-coumarin complex by electrochemical method with increased anticoagulant potency

Abstract

The formation of complexes of coumarin and Zn(II) was studied in aqueous media at pH 8.2±0.1 by polarography and spectroscopy. The polarogram indicated formation of complexes between coumarin and Zn(II). Coumarin produces a well-defined direct current polarogram and differential pulse polarogram in 1 m ammonium tartrate (supporting electrolyte) at pH 8.2±0.1. The stoichiometry of the Zn(II)-coumarin complex is 1:1. Anticoagulant studies on the drug and its metal complex have been performed in albino mice, revealing the complex to be more potent in anticoagulation activity compared to the parent drug.

Keywords

• coumarin
• differential pulse polarography (dpp)
• direct current polarography (dcp)
• prothrombin time
• zinc complex