Nature Communications (May 2021)

Non-productive angiogenesis disassembles Aß plaque-associated blood vessels

  • Maria I. Alvarez-Vergara,
  • Alicia E. Rosales-Nieves,
  • Rosana March-Diaz,
  • Guiomar Rodriguez-Perinan,
  • Nieves Lara-Ureña,
  • Clara Ortega-de San Luis,
  • Manuel A. Sanchez-Garcia,
  • Miguel Martin-Bornez,
  • Pedro Gómez-Gálvez,
  • Pablo Vicente-Munuera,
  • Beatriz Fernandez-Gomez,
  • Miguel A. Marchena,
  • Andrea S. Bullones-Bolanos,
  • Jose C. Davila,
  • Rocio Gonzalez-Martinez,
  • Jose L. Trillo-Contreras,
  • Ana C. Sanchez-Hidalgo,
  • Raquel del Toro,
  • Francisco G. Scholl,
  • Eloisa Herrera,
  • Martin Trepel,
  • Jakob Körbelin,
  • Luis M. Escudero,
  • Javier Villadiego,
  • Miriam Echevarria,
  • Fernando de Castro,
  • Antonia Gutierrez,
  • Alberto Rabano,
  • Javier Vitorica,
  • Alberto Pascual

DOI
https://doi.org/10.1038/s41467-021-23337-z
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 16

Abstract

Read online

Aß are extracellular deposits relevant in Alzheimer’s disease (AD). This study shows that Aß plaques are hubs of endothelial disassembly that induce non-productive angiogenesis. This process is aided by the microglia and unchained by reduced presenilin function, a trait of AD, in endothelial cells.