The Role of Exosomal microRNA in Cancer Drug Resistance

Qiao-ru Guo; Qiao-ru Guo; Hui Wang; Ying-da Yan; Yun Liu; Chao-yue Su; Hu-biao Chen; Yan-yan Yan; Rameshwar Adhikari; Qiang Wu; Qiang Wu; Jian-ye Zhang; Jian-ye Zhang

doi:10.3389/fonc.2020.00472

Frontiers in Oncology (Apr 2020)

The Role of Exosomal microRNA in Cancer Drug Resistance

Qiao-ru Guo,
Qiao-ru Guo,
Hui Wang,
Ying-da Yan,
Yun Liu,
Chao-yue Su,
Hu-biao Chen,
Yan-yan Yan,
Rameshwar Adhikari,
Qiang Wu,
Qiang Wu,
Jian-ye Zhang,
Jian-ye Zhang

Affiliations

Qiao-ru Guo: Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China
Qiao-ru Guo: Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University, Haikou, China
Hui Wang: Guangzhou Institute of Pediatrics/Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China
Ying-da Yan: Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China
Yun Liu: Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China
Chao-yue Su: Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China
Hu-biao Chen: School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China
Yan-yan Yan: Collaborative Innovation Center for Cancer, Institute of Respiratory and Occupational Diseases, Medical College, Shanxi Datong University, Datong, China
Rameshwar Adhikari: Research Centre for Applied Science and Technology, Tribhuvan University, Kirtipur, Nepal
Qiang Wu: Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University, Haikou, China
Qiang Wu: Key Laboratory of Emergency and Trauma of Ministry of Education, School of Tropical Medicine and Laboratory Medicine, Hainan Medical University, Haikou, China
Jian-ye Zhang: Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China
Jian-ye Zhang: Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University, Haikou, China

DOI: https://doi.org/10.3389/fonc.2020.00472
Journal volume & issue: Vol. 10

Abstract

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Exosomes affect the initiation and progression of cancers. In the tumor microenvironment, not only cancer cells, but also fibroblasts and immunocytes secrete exosomes. Exosomes act as a communicator between cells by transferring different cargos and microRNAs (miRNAs). Drug resistance is one of the critical factors affecting therapeutic effect in the course of cancer treatment. The currently known mechanisms of drug resistance include drug efflux, alterations in drug metabolism, DNA damage repair, alterations of energy programming, cancer stem cells and epigenetic changes. Many studies have shown that miRNA carried by exosomes is closely associated with the development of drug resistance mediated by the above-mentioned mechanisms. This review article will discuss how exosomal miRNAs regulate the drug resistance.

Published in Frontiers in Oncology

ISSN: 2234-943X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.frontiersin.org/journals/oncology/

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Abstract

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